Renal Collecting Duct NOS1 Maintains Fluid–Electrolyte Homeostasis and Blood Pressure
نویسندگان
چکیده
منابع مشابه
Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure.
Nitric oxide is a pronatriuretic and prodiuretic factor. The highest renal NO synthase (NOS) activity is found in the inner medullary collecting duct. The collecting duct (CD) is the site of daily fine-tune regulation of sodium balance, and led us to hypothesize that a CD-specific deletion of NOS1 would result in an impaired ability to excrete a sodium load leading to a salt-sensitive blood pre...
متن کاملRenal Collecting Duct Cells
1 2 August 3, 2012 3 Revised: August 6, 2012 4 5 Quantitative Phosphoproteomics in Nuclei of Vasopressin-Sensitive 6 Renal Collecting Duct Cells 7 8 9 Steven J. Bolger*, Patricia A. Gonzales Hurtado*, Jason D. Hoffert, Fahad Saeed, Trairak 10 Pisitkun, and Mark A. Knepper 11 12 *Co-First Authors 13 14 Epithelial Systems Biology Laboratory, 15 NHLBI, National Institutes of Health, 16 Bethesda, M...
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Over 26,000 manuscripts have been published dealing with endothelins since their discovery 25 years ago. These peptides, and particularly endothelin-1 (ET-1), are expressed by, bind to, and act on virtually every cell type in the body, influencing multiple biological functions. Among these actions, the effects of ET-1 on arterial pressure and volume homeostasis have been most extensively studie...
متن کاملRole of collecting duct renin in blood pressure regulation.
Numerous studies indicate that renin is synthesized and secreted by the collecting duct (CD). CD-derived renin may act directly on intercalated and/or principal cells through direct interaction with prorenin receptors and/or through cleavage of proximal tubule-derived angiotensinogen to ultimately produce angiotensin II and activate AT1 receptors. Preliminary studies suggest that the net effect...
متن کامل[Collecting duct renal cell carcinoma].
INTRODUCTION Bellini's renal cell collecting duct carcinoma is a rarely prevalent renal tumour, with low cancer-specific survival, although its rate of response to antiangiogenic therapies is unknown. OBJECTIVES We retrospectively revise a series of collecting duct tumours, with special emphasis on the indication of target therapies and on their results. MATERIALS AND METHODS Retrospective ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2013
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.113.01291